This copyrighted material is provided by Natural Medicines Comprehensive Database Consumer Version. This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. 2013;45(4):417-8. CONDITIONS OF USE AND IMPORTANT INFORMATION: This information is meant to supplement, not replace advice from your doctor or healthcare provider and is not meant to cover all possible uses, precautions, interactions or adverse effects. Monitor your blood pressure closely. Dietary supplements: what you need to know. It's best to talk to your doctor before you start taking antidepressants and vitamins, especially mixed supplements. Ashwagandha (Withania somnifera) is a natural herb used for centuries in Ayurveda. Hypothyroidism, After Thyroid Removal. It may also interact with other herbs, supplements, and even foods. Ashwagandha is purported as useful for relieving stress, fatigue, pain and gastrointestinal problems, and treating diabetes, rheumatoid arthritis and epilepsy. glipizide, glyburide, glimepride), SGLT2 Inhibitors (e.g. For insomnia, a dose of 600 milligrams per day has been found to be safe and effective. Participants of this study received either a placebo or 300 milligrams of ashwagandha twice per day for eight weeks. Long-term safety studies on ashwagandha are lacking. 2020;12(2):e7083. Expert Rev Clin Pharmacol. PLoS One 2009;4:e6628. Curr Clin Pharmacol. Does Ashwagandha interact with other medications? Find - Forest Raga Be sure to let your doctor know if you plan on adding ashwagandha to your medication list so you can be appropriately monitored. Mishra LC, Singh BB, Dagenais S. Scientific basis for the therapeutic use of Withania somnifera (ashwagandha): a review. For more information, read the "What else do I need to know?" section below. Effects of L-Theanine administration on stress-related symptoms and cognitive functions in healthy adults: a randomized controlled trial. It is just a general precaution that ashwagandha may decrease blood sugar. As with many other herbal supplements, little research is available on possible interactions. This article provides a review of the potential uses of ashwagandha. 2021;2021:8254344. doi:10.1155/2021/8254344, Choudhary D, Bhattacharyya S, Bose S. Efficacy and Safety of Ashwagandha (Withania somnifera (L.) Dunal) root extract in improving memory and cognitive functions. Bhat, J., Damle, A., Vaishnav, P. P., Albers, R., Joshi, M., and Banerjee, G. In vivo enhancement of natural killer cell activity through tea fortified with Ayurvedic herbs. Ashwagandha supplements come in various forms, including capsules, gummies, caplets, liquid extracts, and powders. View abstract. I recommend taking it at bedtime for a better night's rest or you can take it during the day. Ashwagandha - Benefits | Side-Effects | Safety Concerns | Interactions Ashwagandha interferes with immunoassay measurements of digoxin, a medication primarily used for treating congestive heart failure and abnormal heart rhythms. Ashwagandha can also interact with some medications and affect how they work. View abstract. Data sources include IBM Watson Micromedex (updated 2 Apr 2023), Cerner Multum (updated 17 Apr 2023), ASHP (updated 10 Apr 2023) and others. 2004;42(12):2015-2020. A randomized double blind placebo controlled study of ashwagandha on generalized anxiety disorder. Supplements That Are Similar to Ashwagandha. Drugs.com provides accurate and independent information on more than 24,000 prescription drugs, over-the-counter medicines and natural products. In rare cases, ashwagandha may cause liver damage. A systematic review and meta-analysis of randomized controlled trials. According to their lab study, withanone may interfere with DNA, leading to liver damage. Moreover, researchers also noted several limitations of the studies included, such as the varying methods used to assess sleep quantity and quality. 2022;15(9):1067-1080. doi:10.1080/17512433.2022.2121699, Salve J, Pate S, Debnath K, Langade D. Adaptogenic and anxiolytic effects of Ashwagandha root extract in healthy adults: a double-blind, randomized, placebo-controlled clinical study. Ashwagandha is purported as useful for relieving stress, fatigue, pain and gastrointestinal problems, and treating diabetes, rheumatoid arthritis and epilepsy. Studies on immunomodulatory activity of Withania somnifera (Ashwagandha) extracts in experimental immune inflammation. Bhattacharya SK, Satyan KS, Ghosal S. Antioxidant activity of glycowithanolides from Withania somnifera. Gastrointestinal side effects including nausea, vomiting and diarrhoea. Do note that ashwagandha itself does not . From the study results, researchers concluded that ashwagandha improved memory and focus. Ashwagandha has no known moderate interactions with any drugs. What are some herbs that are contraindicated with Cotellic (cobimetinib)? According to one study that examined ashwagandha's effect on athletics, ashwagandha may improve both endurance and recovery in healthy adult athletes. It may also interact with other herbs, supplements, and even foods. PLoS One. Sharma AK, Basu I, Singh S. Efficacy and safety of Ashwagandha root extract in subclinical hypothyroid patients: a double-blind, randomized placebo-controlled trial. Ashwagandha may be toxic to the liver (hepatotoxic). The combination could decrease the effectiveness of these medications. View abstract. Ashwagandha has mild interactions with at least 29 different drugs. J.Altern.Complement Med. Effects of Withania somnifera in patients of schizophrenia: a randomized, double blind, placebo controlled pilot trial study. National Center for Complementary and Integrative Health. Staff, Cotellic With Turmeric And Black Pepper Interaction. Effect of standardized root extract of ashwagandha (Withania somnifera) on well-being and sexual performance in adult males: a randomized controlled trial. Kuppurajan K, Rajagopalan SS, Sitoraman R, and et al. Panda S, Kar A. Withania somnifera and Bauhinia purpurea in the regulation of circulating thyroid hormone concentrations in female mice. Akhgarjand C, Asoudeh F, Bagheri A, et al. When people can't obtain all of the nutrients the Food and Drug Administration recommends, they typically look into taking supplements. 1985;23(4):177-183. J Ethnopharmacol. 1993;31(7):607-611. These include wheezing; chest tightness; fever; itching; bad cough; blue skin color; seizures; or swelling of face, lips, tongue, or throat. Some benzodiazepine drugs include alprazolam, known as the brand Xanax; clonazepam, known as Klonopin; diazepam, known as Valium; lorazepam, known as Ativan; and triazolam, known as Halcion. By Mayo Clinic Staff Herbal supplements are natural, so they must be safe, right? J Clin Psychiatry. Ultimately, the supplements and foods you can safely ingest depend entirely on the antidepressant. Ashwagandha is not naturally found in foods, which means the only way to get it is through supplements. 2021 Nov 30;2021:8254344. Still, a seal of approval from one of these agencies is your best bet for supplement quality since dietary supplements and herbs are not regulated in the United States. Ashwagandha may help the body cope with stress. Bhattacharya, S. K. and Muruganandam, A. V. Adaptogenic activity of Withania somnifera: an experimental study using a rat model of chronic stress. This information may not fit your specific health circumstances. It is also important to note that ashwagandha may interact with certain medications, such as immunosuppressants and sedatives. Hydroxyzine: Generic, Uses, Side Effects, Dosages - RxList 2022 Mar 25;14(3):e23494. With such a long list of claims, it's important to look closely at the research. Tumori 8-31-1994;80(4):306-308. Indian J Pharmacol. 13 Supplement or Medication Combos You Should Never Mix Arch Pathol Lab Med 2007;131:1298-303. Therefore, it is important to talk to your healthcare provider about any supplements you plan to take and check in about potential interactions with other supplements or medications. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances. If you have blood sugar problems, keep hard candies, glucose tablets, liquid glucose, or juice on hand for low blood sugar. Supplement use should be individualized and vetted by a healthcare professional, such as a registered dietitian, pharmacist, or healthcare provider. The ashwagandha root extract has been used for thousands of years as an herbal remedy in Ayurveda, the ancient Indian medical system. Gopal S, Ajgaonkar A, Kanchi P, et al. Studies are inconclusive, but ashwagandha may have immune-stimulating properties. View abstract. and treatment options, including any risks or benefits regarding use of medications. Cheah KL, Norhayati MN, Husniati Yaacob L, Abdul Rahman R. Effect of Ashwagandha (Withania somnifera) extract on sleep: A systematic review and meta-analysis. Do not use this product if you have stomach problems or ulcers. View abstract. View abstract. 2020;12(4):1119. Sleep Med. View abstract. Baker C, Kirby JB, O'Connor J, Lindsay KG, Hutchins A, Harris M. The perceived impact of ashwagandha on stress, sleep quality, energy, and mental clarity for college students: qualitative analysis of a double-blind randomized control trial. According to the Cleveland Clinic, there are six different types of medications commonly used to treat depression. The study took place over 10 weeks, and participant results were assessed based on sleep onset latency, total sleep time, sleep efficiency, and wake after sleep onset. Phase III randomized clinical trial of BV-4051, an Ayurvedic polyherbal formulation in moderate SARS-CoV-2 infections and its impact on inflammatory biomarkers. Ashwagandha Side Effects + Drug Interactions - Vida Optima Will Ashwagandha Interact With Diabetic Meds Singh, R. H., Narsimhamurthy, K., and Singh, G. Neuronutrient impact of Ayurvedic Rasayana therapy in brain aging. Within this specific study, participants were randomized to receive a placebo (sugar pill with no active ingredients), an ashwagandha dose of 250 milligrams (mg) per day or 600 milligrams per day. There is animal research that suggests that ashwagandha may lower systolic and diastolic blood pressure, putting people who take blood pressure-lowering medication at risk for hypotension,. Safety of ashwagandha root extract: a randomized, placebo-controlled, study in healthy volunteers. This product can contain high amounts of iron. J Ayurveda Integr Med. Ashwagandha interacts with several types of prescription medicine, so consult your health care provider before taking this herbal remedy. When taken inappropriately, ashwagandha can have side effects and potentially serious medicinal interactions. View abstract. These side effects are usually experienced on higher doses. This can result in serotonin syndrome, which causes side effects like anxiety, sweating, confusion, tremors, lack of coordination and an accelerated heart rate. Health Sci Rep 2022;5(4):e741. View abstract. Ahumada F, Aspee F, Wikman G, and et al. Researchers from another review concluded that ashwagandha might be useful in conditions such as: Studies used in this review included human, animal, and lab research. Therefore, it is recommended to consult with a healthcare professional before adding ashwagandha to a weight loss plan, especially if you have any underlying medical conditions or are taking any medications . 1981;19(3):245-249. For professional medical information on natural medicines, see Natural Medicines Comprehensive Database Professional Version. J R Coll Physicians Edinb. Bjrnsson HK, Bjrnsson ES, Avula B, et al. 2021;272:113929. doi:10.1016/j.jep.2021.113929, Bonilla DA, Moreno Y, Gho C, Petro JL, Odriozola-Martnez A, Kreider RB. Other essential vitamins and minerals may also be helpful in treating depression. Medically reviewed by Drugs.com. doi:10.7759/cureus.5797, Cheah KL, Norhayati MN, Husniati Yaacob L, Abdul Rahman R. Effect of ashwagandha (Withania somnifera) extract on sleep: a systematic review and meta-analysis. People who are pregnant or breastfeeding should avoid using the herb, as not enough is known about its safety. Prez-Gmez J, Villafaina S, Adsuar JC, Merellano-Navarro E, Collado-Mateo D. Effects of ashwagandha (Withania somnifera) on VO2max: A systematic review and meta-analysis. Medicine (Baltimore). A double-blind, randomized, placebo-controlled trial on the effect of Ashwagandha (Withania somnifera dunal.) Indian J Exp Biol 1997;35:236-9. Of the 58 participants in the study, those who took ashwagandha had reduced levels of cortisol (a stress hormone) as well as lower perceived stress scores by the end of the eight-week study. All rights reserved. There are no vitamins contraindicated for consumption with antidepressants, but you should be cautious about consuming a mixture of supplements. View abstract. Some research has proven that this may indeed be true. Deocaris, C. C., Widodo, N., Wadhwa, R., and Kaul, S. C. Merger of ayurveda and tissue culture-based functional genomics: inspirations from systems biology. View abstract. Safety and adverse events were also not well-reported in the studies used in the review. 2019;11(9):e5797. It may cause you to become sleepy or drowsy. Sleep Sci. Phytother Res. OTHER NAME(S): Ajagandha, Amangura, Amukkirag, Asan, Asana, Asgan, Ashwagandha has most often been used by adults in doses up to 1000 mg daily, for up to 12 weeks. This is one of the more common food-drug reactions. Doses higher than that may interact with lexapro, or produce more pronounced effects. Nonetheless, additional large-scale, long-term studies would strengthen these findings. Also learn why ingredients such as alpha-lipoic acid, soy, resveratrol, quercetin may impair thyroid function. Ashwagandha has no known moderate interactions with any drugs. Evid Based Complement Alternat Med. Lu, L., Liu, Y., Zhu, W., Shi, J., Liu, Y., Ling, W., and Kosten, T. R. Traditional medicine in the treatment of drug addiction. Certain supplements may contain ingredients that are dangerous when mixed with specific medications, even if they are safe on their own. Anxiety Medication Interactions: What Should We Be Aware Of - GoodRx Efficacy of Withania somnifera supplementation on adult's cognition and mood. Kaur, K., Rani, G., Widodo, N., Nagpal, A., Taira, K., Kaul, S. C., and Wadhwa, R. Evaluation of the anti-proliferative and anti-oxidative activities of leaf extract from in vivo and in vitro raised Ashwagandha. Ahmad MK, Mahdi AA, Shukla KK, et al. Some products may not mix well with other drugs or natural products. 2017 Jan;22(1):96-106 View abstract. Ashwagandha drug interactions | HealthTap Online Doctor Ghosal S, Lal J, Srivastava R, and et al. Hidese S, Ogawa S, Ota M, et al. 1992;30(3):169-172. View abstract. A study compared ashwagandha to a placebo to determine whether the herb would have a positive effect on insomnia. Cancer Lett 2000;148:9-17. doi:10.1097/MD.0000000000017186, Pratte MA, Nanavati KB, Young V, Morley CP. Dasgupta A, Tso G, Wells A. Indian J Physiol Pharmacol. Curr Res Toxicol. View abstract. Ashwagandha: Benefits, Side Effects, Dosage, and Interactions Usually ashwagandha is taken 1000 mg per day, for the course of 3 to 4 months. Ashwagandha might cause sleepiness and slowed breathing. Answered by Dr. Brian Staiger, PharmD Dr. Brian Staiger also has herbalist training and educational certificates in the field of medical ethnobotany. Levothyroxine is in the drug class thyroid drugs . The liver damage never progressed to liver failure, and most cases were resolved within five months. Just be sure to choose a supplement from a reputable manufacturer and follow the . They also are not very good drugs, because they have multiple potentially . Some medications, such as those used after a transplant, decrease the activity of the immune system. 2001;75(2-3):165-168. Agnihotri AP, Sontakke SD, Thawani VR, Saoji A, Goswami VS. A total of 0 drugs are known to interact with ashwaganda. Be sure to tell your doctor if you are breastfeeding. Varying levels of research have looked at the potential benefits of ashwagandha. View abstract. Some don't work well with prescription medicines. J Ethnopharmacol 1991;33:91-5. In this investigation, participants took either a placebo or 240 milligrams per day of ashwagandha extract. Does Ashwagandha Interact With Prescription Drugs? Go to the ER right away. View abstract. View abstract. View abstract. hydrochlorothiazide, spironolactone, chlorthalidone). This is because ashwagandha is thought to be an adaptogen, a substance that may help the body resist stress. However, SSRIs don't work for everyone, and other antidepressants work via different pathways in your body. The best time to take ashwagandha is at the time that works best for you. Nat.Prod.Res 2005;19(6):567-571. View abstract. The roots can be used topically as a poult. These severity listings are for informational use only. Copyright 2023 UpToDate, Inc. and its affiliates and/or licensors. View abstract. She founded the Fad Free Nutrition Blog and Nutricion al Grano websites and is based in Texas. 2012;34(3):255-62. Sharada, A. C., Solomon, F. E., Devi, P. U., Udupa, N., and Srinivasan, K. K. Antitumor and radiosensitizing effects of withaferin A on mouse Ehrlich ascites carcinoma in vivo. Some vitamins and supplements can interfere with blood-thinning blood pressure drugs, Dr. Glatter says. Ashwagandha Uses, Benefits & Dosage - Drugs.com Herbal Database Fortunately, no cases resulted in liver failure, and all recovered. Although, it's important to note that long-term studies have not been performed on ashwagandha. Twelve studies were included in the final review, and researchers concluded that ashwagandha showed more improvements in physical performance than placebo pills. The Journal of Psychiatry study reported that omega-3 fats and vitamin D are the two essential nutrients that are most likely to help reduce depression symptoms. National Center for Complementary and Integrative Health. Yakugaku Zasshi 2008;128(8):1159-1167. View abstract. Researchers of the study believed that these results were due to the ability of ashwagandha to moderate the body's stress response. It also covers possible side effects of the herb, interactions, dosage information, and guidance regarding selecting ashwagandha supplements. Integr Cancer Ther. Patients must speak with a health care provider for complete information about their health, medical questions, and treatment options, including any risks or benefits regarding use of medications. Cureus. Begum, V. H. and Sadique, J. Therapeutic Research Faculty 2020. Dosage: How Much Ashwagandha Should I Take? Medical Content Reviewed By HelloPharmacist doi:10.7759/cureus.6466, Lopresti AL, Smith SJ, Malvi H, Kodgule R. An investigation into the stress-relieving and pharmacological actions of an ashwagandha (Withania somnifera) extract: a randomized, double-blind, placebo-controlled study. 2020;34(5):1041-1059. St. John's wort can cause a buildup of serotonin in the body when taken with antidepressants. Are there any side effects of ashwagandha? Ambiye VR, Langade D, Dongre S, Aptikar P, Kulkarni M, Dongre A. Taking ashwagandha with sedative medications might cause breathing problems and/or too much sleepiness. Am J Ther 2023;30(1):e80-e83. According to the NIH, ashwagandha may interact with certain prescription medications, including antidiabetes drugs, antihypertensive drugs, immunosuppressants, benzodiazepines, certain sedative . DISCLAIMER: Currently this does not check for drug . View abstract. Dietary supplements are not regulated like drugs in the United States, meaning the Food and Drug Administration (FDA) does not approve them for safety and effectiveness before products are marketed. Taking it with drugs that increase levels of thyroid hormone (e.g. However, some other statins do not seem to be affected by grapefruit juice, including pravastatin (Pravachol), fluvastatin (Lescol) and rosuvastatin (Crestor). Thyroid Suppression Test. Adaptogenic Herbs And Their Interaction With Medications - Thyroid Nation Does Ashwagandha Interact With Any Medications? These include drugs like thyroid desiccated, levothyroxine, or liotrix. However, you should not stop taking any prescribed medication. Pharmacol Biochem.Behav 2003;75(3):547-555. View abstract. There is little evidence for its use as an "adaptogen." Ashwagandha contains chemicals that might help calm the brain, reduce swelling, lower blood pressure, and alter the immune system. Ashwagandha has also been used to increase performance among athletes and improve male infertility. Side Effects Of Ashwagandha: 5 Things To Be Aware Of - CureJoy Ashwagandha-induced liver injury: A case series from Iceland and the US Drug-Induced Liver Injury Network. Ashwagandha is an evergreen shrub that grows in Asia and Africa. To prolong shelf life, ashwagandha supplements should be stored in a cool, dry place. . Ashwagandha - Special Subjects - Merck Manuals Consumer Version View abstract. While the side effects of ashwagandha are minimal, some people may experience: Gastrointestinal upset. Indian J Physiol Pharmacol. There aren't any specific antidiabetic drugs ashwagandha is known to interact with. Take extra care and check with your doctor if you have: Signs of a very bad reaction. Anyone with upcoming surgery should stop using ashwagandha at least two weeks prior. The combination could result in excess thyroid hormone in the body, which has many negative effects. J Atten Disord 2010;14:281-91. If you're interested in taking a nutritional supplement to support your treatment for depression, talk to your doctor so you can find the one that works best for you and doesn't affect your antidepressants. We can, however, make some educated guesses on drug interactions based on ashwagandha works, and the effects it is known to have. After eight weeks, statistically significant improvements were seen in both aerobic capacity and recovery for those who took ashwagandha. Headache. J Diet Suppl. I have it on my medical HelloPharmacist View abstract. Effect of Asian ginseng, Siberian ginseng, and Indian ayurvedic medicine Ashwagandha on serum digoxin measurement by Digoxin III, a new digoxin immunoassay. . Sriranjini SJ, Pal PK, Devidas KV, Ganpathy S. Improvement of balance in progressive degenerative cerebellar ataxias after Ayurvedic therapy: a preliminary report. Some herbal supplements with antidepressant properties are safe to consume alongside medications. Bonilla DA, Moreno Y, Gho C, Petro JL, Odriozola-Martnez A, Kreider RB. View abstract. View abstract. This includes: As with many other herbs and supplements, ashwagandha has a risk of side effects. Chitre D, Nadkarni S, Jagtap N, et al. The use of this information is governed by the Terms of Use, available at https://www.wolterskluwer.com/en/know/clinical-effectiveness-terms. Herbal supplements can strongly affect the body. Does Ashwagandha Interact With Any Medications? Since you don't mention any drugs in your question, we'll list some of the potential interactions below. Synthroid and interactions: Food, alcohol, and more - Medical News Today Bhattacharya, S. K., Bhattacharya, A., Sairam, K., and Ghosal, S. Anxiolytic-antidepressant activity of Withania somnifera glycowithanolides: an experimental study. Liver Int. Khattak, S., Saeed, Ur Rehman, Shah, H. U., Khan, T., and Ahmad, M. In vitro enzyme inhibition activities of crude ethanolic extracts derived from medicinal plants of Pakistan. Sedatives: Since ashwagandha can both energize and induce restorative sleep, it might negate or amplify the effect of other sedative drugs, especially the benzodiazepines. It should not be confused with Physalis alkekengi, which is also referred to as winter cherry. J Funct Morphol Kinesiol. Hence, be cautious if taking these medications and want to take Ashwagandha also. Some of these interactions can be life-threatening. Naturopathic care for anxiety: a randomized controlled trial ISRC TN78958974. This herb used in alternative medicine may help reduce stress. Some but not all ashwagandha supplements are organic. View abstract. No, Ashwagandha does not possess any qualities that cause it to be habit forming, and the risk of forming an addiction to Ashwagandha is little to none. View abstract. The effect of total alkaloids on the smooth muscles. This means they can cause drug-drug interactions, and they can have all the usual side effects and risks that pharmaceutical can have. Thank you, {{form.email}}, for signing up. If you take a drug meant to suppress your immune systems, such as methotrexate or mycophenolate, they may have conflicting effects. Pusec CM, Wolsky R, Llerena C, Sura P. A Case of Supplement-Induced Hepatitis. At the end of the study, significant improvements in general memory and immediate memory were seen in the ashwagandha group. Ven Murthy, M. R., Ranjekar, P. K., Ramassamy, C., and Deshpande, M. Scientific basis for the use of Indian ayurvedic medicinal plants in the treatment of neurodegenerative disorders: ashwagandha. Singh P, Salman KA, Shameem M, Warsi MS. Withania somnifera (L.) Dunal as add-on therapy for COPD patients: a randomized, placebo-controlled, double-blind study. Cent.Nerv.Syst.Agents Med.Chem. Taking ashwagandha along with medications that lower blood pressure might cause blood pressure to go too low. It is also recommended that people with hormone-sensitive prostate cancer avoid using ashwagandha due to possible hormone changes caused by the herb. Biswal BM, Sulaiman SA, Ismail HC, Zakaria H, Musa KI. Some medications, called sedatives, can also cause sleepiness and slowed breathing. Withania somnifera extract. Byetta, Trulicity, Ozempic, Rybelsus, Bydureron, Victoza, Mounjaro), Sulfonylureas (e.g. J Res Ayur Sid 1980;1:370-385. View abstract.
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